CryoSure® it

Our mission

Lives are at risk when the challenges in cold chain shipping result in ruined pharmaceuticals. Our mission was to create the easiest and safest dry ice shipping solution that reduces the risks and delivers your most treasured pharma product in perfect condition. Based on the Linde Seccurus® technology and Envirotainer’s extensive industry experience, we are proud to present the CryoSure® platform. With superior duration and unmatched performance CryoSure® is a product of that mission.

Learn more about the 8 key benefits of the CryoSure® platform and how we put it to the test

01. Superior duration up to 3 weeks

ISTA 7D summer profile validated for below -70°C between 8 and 21 days depending on size.

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02. Easy to handle

Pre-packed, pre-conditions and ready-to-go.

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03. Lighter carbon footprint

Completely reusable platform with 50-70% less weight to reduce emissions.

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04. Performance not affected by orientation

Sublimation rate and duration stays the same, no matter the orientation.

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05. Heat resistant

All models can withstand ambient temperatures of up to at least 60°C, while maintaining below -70°C inside

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06. Maintains -70°C if opened

Can be opened and closed without risking the product inside.

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07. Real-Time Visibility

DuraWatch® keeps track of the remaining duration for your shipment and it is also possible to add live monitoring enabling real time location, temperature etc.

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08. Robust Design

Made from high-grade and durable aluminum, the CryoSure® dewar is delivered inside a sturdy, foam-filled cardboard box for additional protection and easier stacking

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The challenges and solutions

No dry ice refills needed for up to 3 weeks.

Identified challenges:

International shipments of pharma products often require longer duration than expected. Supply chain issues, flight delays, and most common, customs delays risk the integrity of the product as the solutions run out of dry ice. Logistics providers do offer dry ice refilling services, but the main issues related to these services are risks of temperature excursions when opening a box, and difficulties for the couriers to access the custom holds.

In testing environments, box providers usually show good duration results when the temperature logger is covered in dry ice. The logger still shows good results due to it sinking with the level of dry ice inside the box, even though the product itself is exposed to higher temperatures. Consequently, despite showing a duration of 5-6 days, the actual holding time below -70°C is around 2-3 days.

CryoSure® solution:

The CryoSure® platform is the most secure solution on the market. With an ISTA 7D summer profile validation, below -70°C for between 8 and 21 days, depending on the model makes it 2-7 times longer than any competing technology.

Official tests report: ISTA 7D Summer profile tests for all models. 6 units tested, 3 with maximum load and 3 with minimum load. And real-life tests of 15 air shipments and 15 ground shipments for the X2 inside of the US.
CryoSure® makes -70°C shipping a piece of cake.

Identified challenges:

Dry ice shipments can be a cumbersome and risky preparation process; packaging material has to be ordered separately and dry ice must be sourced. A manual process with many different steps also makes room for a lot of mistakes, which in turn leads to multiple temperature excursions due to the risks of handling.

CryoSure® solution: Arrives pre-packed and ready, eliminating the risks of handling. Just open it up, put the product in and ship it off.
Safer for your cargo. Safer for the planet.

Identified challenges:

Millions of shipments per year make their way to different destinations resulting in landfills, so does its packaging. Existing dry ice boxes are bulky and inflexible, resulting in less efficient handling and unnecessary volume. Heavy systems drive emissions which negatively impact the environment as well.

CryoSure® solution: The CryoSure® platform is noticeably less bulky and has 2 to 3 times higher weight-to-volume efficiency than existing dry ice boxes and (LN₂) solutions, significantly reducing both transportation costs and carbon emissions. Made with recyclable box material that has major positive impact eliminating the need for landfill at the destination, and 50-70% less weight to reduce emissions. The platform is also completely reusable, so ask us to come pick it up, or simply return it to one of our 50+ service stations globally.
Has your shipment taken a tumble? Don’t worry, orientation won’t affect temperature or duration.

Identified challenges:

Shipments have to be handled with care. Most temperature excursions occur when dry ice sublimates as a result of tilted boxes. For liquid nitrogen (LN₂) shipments, the technology itself does not allow for the box to be tilted since orientation heavily impacts performance. If shipped sideways, duration goes down by more than 40%, and if upside down by more than 70%. This forces the users to pay for expensive add-ons which add weight and complexity to the shipment.

CryoSure® solution: Performance not affected by orientation.

Official test: Additional orientation tests for certain models are made.
How do you keep your cargo cool when customs are blazing hot?

Identified challenges:

A box left in high temperatures would mean a disaster for the product, that is why airport tarmacs, but also warehouses and trucks are high-risk environments.

CryoSure® solution: Can be exposed to high temperatures with no risk for the product inside

Official tests: Extreme temperature tests up to 60°C, with sustained performance.
Check, check, and check again. CryoSure® keeps cool even if opened.

Identified challenges:
Dry ice sublimates very fast, especially when exposed to higher temperatures. The standard operating procedure for specialty couriers is to open the boxes to check dry ice levels every 24h during a shipment – jeopardizing the product every time.

CryoSure® solution: The system can be opened and closed without affecting the product inside.

Official tests: In the making, not yet in place.
Double-check on your cargo – anytime, from anywhere.

Identified challenges:

Until today, no system has been able to keep track of when the dry ice was filled and the remaining duration. When staff on the ground lack information about how long the shipment has been out for, boxes are often opened for status checks, risking the product inside.

CryoSure® solution: Logging all events in the systems and enabling live monitoring of your shipment in terms of location, temperature, light, shock, humidity and remaining duration in real-time. All through DuraWatch®.
We can’t eliminate human error. But we have created CryoSure® to withstand it.

Identified challenges:

Human error is always a risk when handling fragile shipments. Transportation-related mistakes and tilting of products are the reasons for most dry ice sublimation and damaged products. The technology for liquid nitrogen (LN₂) shipments also doesn’t allow for the box to be tilted due to performance impact. The users are forced to use expensive add-ons making the shipment heavier and more complex.

CryoSure® solution: Made from high-grade and durable aluminum, the CryoSure® dewar is delivered inside a sturdy, foam-filled cardboard box for additional protection and easier stacking for the ultimate performance.

Features and Performance

ISTA 7D validated for below -70°C for between 8 and 21 days.
The CryoSure® always arrives pre-conditioned and ready-to-to eliminating the need for any box assemly or dry ice sourcing
The CryoSure® platform maintains the temperature stable at below -70°C throughout the entire shipment period regardless of orientation.
The sample space maintains its temperature around or below -70°C even if it is opened.

Specifications for X1, X2, X5, X11

Download manual and technical specifications.

Envirotainer CryoSure User Manual.pdf

Envirotainer CryoSure Unit Tech Specs.pdf

Envirotainer CryoSure Terms and Conditions.pfd

CryoSure^® X1: 9.0 (3.5)

CryoSure^® X2: 9.0 (3.5)

CryoSure^® X5: 15.2 (6.0)

CryoSure^® X11: 21.3 (8.4)
CryoSure^® X1: 4.8 (10.6)

CryoSure^® X2: 9.9 (21.7)

CryoSure^® X5: 11.3 (24.8)

CryoSure^® X11: 16.8 (37.0)
CryoSure^® X1: 1.2 (2.5)

CryoSure^® X2: 3.5 (7.7)

CryoSure^® X5: 3.2 (7.2)

CryoSure^® X11: 5.5 (12.0)
CryoSure^® X1: 8.1x19.5 (3.2x7.7)

CryoSure^® X2: 8.1x31.9 (3.2x12.6)

CryoSure^® X5: 14.3x31.5 (5.6x12.4)

CryoSure^® X11: 20.7x33.2 (8.1x13.1)
CryoSure^® X1: 0.9 (33.7)

CryoSure^® X2: 1.6 (55.0)

CryoSure^® X5: 5.0 (170.3)

CryoSure^® X11: 11.1 (376.3)
CryoSure^® X1: 26.4x40.6 (10.4x16.0)

CryoSure^® X2: 29.0x57.1 (11.4x22.5)

CryoSure^® X5: 33.0x57.1 (13.0x22.5)

CryoSure^® X11: 45.0x62.4 (17.7x24.6)
CryoSure^® X1: >8 days

CryoSure^® X2: >22 days

CryoSure^® X5: >12 days

CryoSure^® X11: >15 days

	# 2 mL vials	2 mL vial configuration
CryoSure^® X1	20	Canister holding 2 bags, 10 vials/bag
CryoSure^® X2	80	Canister holding 16 canes without sleeves, 5 vials/cane
CryoSure^® X2	70	Canister holding 14 canes with sleeves, 5 vials/cane
CryoSure^® X5	300	Canister holding 60 canes without sleeves, 5 vials/cane
CryoSure^® X5	200	2 boxes oriented vertically, 100 vials/box
CryoSure^® X11	600	120 canes without sleeves in bags, 5 vials/cane
CryoSure^® X11	500	Rack holding 5 boxes, 100 vials/box

Envirotainer has been leading the way ever since the beginning of the temperature-controlled shipments and it is with great pride that we now have launched the CryoSure® platform. We believe CryoSure® fills a substantial gap in the cryogenic -70°C shipment market and significantly improves patient safety.

Peter Gisel-Ekdahl CEO at Envirotainer

How it works

Made from high-grade and durable aluminum, the CryoSure® dewar is delivered inside a sturdy, foam-filled cardboard box for additional protection and easier stacking. The product space is chilled to below -70°C with dry-ice pellets charged from the top. The walls are vacuum insulated to ensure minimal heat transfer. This unique design enables the CryoSure® dewars to maintain a stable temperature up to 7 times longer compared to any competing technology.

Ready to order? Customer portal

CryoSure® is available and can be booked through our customer portal today. If you are not an existing customer and would like to become one, please reach out to us and we will start the process.

Customer portal

Would you like to learn more?

If you would like to know more about CryoSure®, do not hesitate to reach out to your local Sales representative or operations center. Envirotainer’s worldwide presence means it is always easy for you to contact us.

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CryoSure^® X1:	9.0 (3.5)
CryoSure^® X2:	9.0 (3.5)
CryoSure^® X5:	15.2 (6.0)
CryoSure^® X11:	21.3 (8.4)

CryoSure^® X1:	4.8 (10.6)
CryoSure^® X2:	9.9 (21.7)
CryoSure^® X5:	11.3 (24.8)
CryoSure^® X11:	16.8 (37.0)

CryoSure^® X1:	1.2 (2.5)
CryoSure^® X2:	3.5 (7.7)
CryoSure^® X5:	3.2 (7.2)
CryoSure^® X11:	5.5 (12.0)

CryoSure^® X1:	8.1x19.5 (3.2x7.7)
CryoSure^® X2:	8.1x31.9 (3.2x12.6)
CryoSure^® X5:	14.3x31.5 (5.6x12.4)
CryoSure^® X11:	20.7x33.2 (8.1x13.1)

CryoSure^® X1:	0.9 (33.7)
CryoSure^® X2:	1.6 (55.0)
CryoSure^® X5:	5.0 (170.3)
CryoSure^® X11:	11.1 (376.3)

CryoSure^® X1:	26.4x40.6 (10.4x16.0)
CryoSure^® X2:	29.0x57.1 (11.4x22.5)
CryoSure^® X5:	33.0x57.1 (13.0x22.5)
CryoSure^® X11:	45.0x62.4 (17.7x24.6)

CryoSure^® X1:	>8 days
CryoSure^® X2:	>22 days
CryoSure^® X5:	>12 days
CryoSure^® X11:	>15 days

Our mission

The challenges and solutions

Features and Performance

Specifications for X1, X2, X5, X11

How it works

Ready to order? Customer portal

Would you like to learn more?

Would you like to get in touch?